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dynamic glp 1 Understanding the activation mechanism of GLP-1R/GIPR by dual agonist Tirzepatide via molecular dynamics and protein-peptide binding

Marsoni M251S
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4.7 ★★★★★
Based on 454 reviews
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Verified Purchase
Jo-Ann Epstein
West Palm Beach, US
★★★★★ 5
Good fit
Material Type: Black - 3 Pairs, Size: X-Large
My husband just started using these and they feel comfortable. Hasn't used them long enough to see if his heels are better. He has a high arch so I bought him the XL and they fit perfectly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
M
Verified Purchase
M.R.
Lowell, US
★★★★★ 5
No more painful cracked heels! These really do work!
Material Type: Black - 3 Pairs, Size: X-Large
These really do work well. This is one of the first winters that I have not experienced painful, cracked heels. They are long lasting, and definitely make my heels smoother and softer after wearing them. For the first few times wearing them I simply went with the moisturizer embedded in them. After a few uses I then covered my heels with Aquaphor Advanced Therapy Healing Ointment. This worked even better, and I would recommend it. I am very glad I bought these. Of note, I have really big feet that are quite wide and the XL are a little snug but not uncomfortably so. I use them overnight, but also have worn them under socks and they work fine.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 3, 2026
K
Verified Purchase
K. Davis
Phoenix, US
★★★★★ 5
Works for foot psoraisis
Size: 2 pairs black L
Got these for work (service industry) to reduce issues with psoriasis and blisters while putting on 20k+ steps a day. Over time the wounds healed and I could work without so much pain. I now don't use them all the time like I used to, only when a new lesion or blister appears, too prevent a breakout. Tip: if you're not in full breakout, wear thick socks under these as a barrier to friction.
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Reviewed in the United States on April 28, 2026
K
Verified Purchase
Kim C
Lowell, US
★★★★★ 4
Work well but run small
Size: 1 pair black L
They do seem to run a bit small. I bought them for my bf but snagged them from him because I couldn’t resist! I’m about a W8/12 and they were just a little big but unlike others, I just put them on while sleeping and didn’t walk around with them. If you’re just planning on that, they did a great job at sloughing and moisturizing 😎
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Reviewed in the United States on April 25, 2026
A
Verified Purchase
Aaron Duncan
West Palm Beach, US
★★★★★ 5
Good socks they work.
Size: 2 pairs black L
I normally wear size 13&half to 14 men's, and these fit me ok. They sit just below the ankle. They can get a little tight for me so you should look out for that if you are on the thicker side. But they work as advertised and help moisturize your feet. I recommend wearing them if you're going to just be hanging around home for a bit in one spot as they can be a little slippery to walk in if you go fast. Would not recommend going up and down stairs.
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Reviewed in the United States on August 28, 2025

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